Debiopharm International SA

Debiopharm International SA Announces Results of 2 Key Oncology Programs at 2015 AACR Conference

Lausanne, Switzerland (ots/PRNewswire) - Debiopharm presents preclinical results for 2 anti-cancer targeted therapies Debio 1143 and Debio 1347

Debiopharm International SA (Debiopharm), part of Debiopharm Group(TM), a Swiss-based global biopharmaceutical company developing prescription drugs that target unmet medical needs as well as companion diagnostics, today announced that preclinical data on the investigational compounds Debio 1143 (SMAC mimetic) and Debio 1347/CH5183284 (FGFR 12,3 inhibitor) will be presented at the 2015 Annual meeting of the American Association for Cancer Research (AACR) taking place in Philadelphia.

"Oncology has and will continue to benefit from combined and targeted therapies. Results from these preclinical studies underscore the potential clinical value of our two anti-cancer targeted therapies" said Dr Nigel McCracken, Vice President, Translational Medicine. "Currently both Debio 1143 and Debio 1347 are in Clinical Development and Debiopharm remains committed to exploring new combinations and new indications to provide improved benefit to patients suffering from cancers".

AACR 2015 Abstract

Compound                        Title                       Date and Time     No.
Debio 1143  SMAC mimetic and radiotherapy synergize to      Sun, Apr 19,     #283
            enhance antitumor immunity in lung cancer by    1:00 - 5:00 pm
            targeting immunosuppressive cells                

            Debio 1143 synergizes with taxanes,             Mon, Apr 20,     #2529
            topoisomerase and bromodomain inhibitors to     1:00 - 5:00 pm
            inhibit growth of lung adenocarcinoma          

            The IAP inhibitor Debio 1143 reverses           Mon, Apr 20,     #2700
            carboplatin resistance in ovarian cancer cells  1:00 - 5:00 pm
            by inducing both apoptosis and necroptosis     

Debio 1347  Characterization of two novel oncogenic         Sun, Apr 19,     #689
            FGFR2 fusions sensitive to the FGFR-selective   1:00 - 5:00 pm
            inhibitor Debio 1347 in cholangiocarcinoma

            Formulation switch and pharmacokinetics/        Mon, April 20,   Abstract
            pharmacodynamics of Debio 1347 (CH5183284), a   8:00 - 12:00 am  CT228
            novel FGFR inhibitor, in a first-in-human dose
            escalation trial in solid tumors patients

            Additional poster regarding Debio 1347 to be    Sun, Apr 19,     Abstract
            presented by Chugai Pharmaceutical, the         1:00 - 5:00 pm   #123
            originator of the compound: Mechanism of
            oncogenic signal activation by the novel
            fusion kinase FGFR3-BAIAP2L1

About Debiopharm International SA

Debiopharm Group(TM) is a Swiss-based global biopharmaceutical group of four companies active in drug development, GMP manufacturing of proprietary drugs, diagnostics, and investments. Debiopharm International SA is focused on the development of prescription drugs that target unmet medical needs. The company in-licenses, develops and/or co-develops promising biological and small molecule drug candidates for global registration. The products are commercialized through out-licensing to pharmaceutical partners to give access to the largest number of patients worldwide.

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